DPPIV: The Digestive Enzyme You Didn’t Know You Needed

Written By Brady Wirick

In the realm of digestive health, one enzyme stands out as a potential game-changer: Dipeptidyl Peptidase-IV (DPPIV). This remarkable enzyme, often abbreviated as DPPIV, plays a crucial role in the breakdown of specific proteins. In this comprehensive blog post, we’ll delve into the fascinating world of DPPIV, exploring its functions, benefits, and the significant impact it can have on our overall well-being. Stick around until the end and I will share with you my favorite source of DPPIV: Glutaxym from US Enzymes!

Understanding DPPIV:

DPPIV is an enzyme classified as a peptidase, a type of enzyme that breaks down proteins into smaller peptides. Specifically, DPPIV acts on dipeptides, which are molecules composed of two amino acids linked together. Its primary role is to snip off certain amino acids from the ends of proteins, facilitating their digestion and absorption in the small intestine.

Digestive Powerhouse:

One of the key benefits of DPPIV is its ability to aid in the digestion of various proteins, particularly those derived from gluten and casein. Gluten, found in wheat and other grains, can be challenging to digest for some individuals. DPPIV steps in to break down gluten into more manageable fragments, potentially easing digestive discomfort associated with gluten consumption.

Gluten Digestion Support:

For individuals with gluten sensitivity or celiac disease, DPPIV supplementation may offer valuable support. Its gluten-digesting capabilities help to degrade gluten proteins into smaller, less immunogenic peptides, potentially reducing the risk of adverse reactions in those sensitive to gluten.

Managing Dairy Intolerance:

Similarly, DPPIV can assist in the breakdown of casein, a protein found in milk and dairy products. Individuals with lactose intolerance or casein sensitivity may find relief in DPPIV supplementation, as it aids in the digestion of casein, potentially minimizing digestive distress.

Blood Sugar Regulation:

Beyond its digestive functions, DPPIV is involved in the regulation of blood sugar levels. DPPIV is known for its role in the inactivation of incretins, hormones that stimulate insulin release in response to food intake. By modulating incretin activity, DPPIV helps regulate blood sugar levels, making it a noteworthy player in glucose homeostasis.

Immune Modulation:

DPPIV’s influence extends beyond the digestive system, reaching into the realms of immune modulation. Some studies suggest that DPPIV may play a role in regulating immune responses, potentially influencing inflammatory processes. While more research is needed to fully understand these connections, the immune-modulating potential of DPPIV adds an intriguing layer to its repertoire of benefits.

Stress and Mood Regulation:

In recent studies, DPPIV has shown promise in its role in managing stress, anxiety, depression, and behavior issues. While the exact mechanisms are still under investigation, it is hypothesized that DPPIV might influence the gut-brain axis, a bidirectional communication system between the gastrointestinal tract and the central nervous system. This suggests that DPPIV supplementation could potentially play a role in supporting mental health and emotional well-being.

The only DPPIV Supplements:

Given its potential benefits, DPPIV supplements have gained popularity as a supportive measure for individuals facing challenges with gluten and casein digestion. These supplements often contain DPPIV sourced from various origins, such as microbial or plant-based sources. There are many reasons why I find Glutaxym to be superior over other brands.

Choosing the Right DPPIV Supplement:

When considering DPPIV supplementation, it’s crucial to choose a high-quality product from a reputable source. Look for supplements that provide a sufficient dose of DPPIV, ensuring its effectiveness in aiding protein digestion. Additionally, consider whether the supplement includes other enzymes or cofactors that enhance its overall efficacy. US Enzymes checks all of these boxes!!!

Integrating DPPIV into Dietary Strategies:

While DPPIV supplements can be a valuable tool, it’s essential to approach dietary choices with mindfulness. Individuals with gluten sensitivity or other digestive concerns should still prioritize a well-balanced and nutrient-dense diet. DPPIV supplements can complement dietary strategies, but they should not replace a healthy and varied eating plan. In other words, DPPIV supplementation, even with Glutaxym, does not give you a free pass to eat whatever you want without consequence!

To learn more about Glutaxym, check out this product information sheet:



In the intricate tapestry of digestive health, DPPIV emerges as a key player with multifaceted benefits. From its pivotal role in protein digestion, particularly gluten and casein, to its potential impact on blood sugar regulation, immune modulation, and mental health, DPPIV showcases a diverse range of contributions to our well-being. Whether through natural food sources or thoughtfully chosen supplements, harnessing the benefits of DPPIV offers a promising avenue for those seeking digestive support, overall health optimization, and emotional well-being. As research continues to unveil the complexities of this enzyme, the future holds exciting prospects for understanding and leveraging the full scope of DPPIV’s potential benefits. After 17 years of clinical practice, one particular brand of DPPIV supplements has stood out compared to others. Glutaxym is hands down the most effective, bioavailable product out there.


Glutaxym cannot be purchased over the counter. Any Glutaxym on Amazon is likely a fake. To order this product, you have to set up an account under my name. A 10% discount code is available.  You can do that by following these directions:

Follow this link to our page: https://usenzymes.com/?rfsn=588806.4d24b0baf 

Click on “account login” and then “register” (Below Register as a patient with an affiliate Doctor)

Use password USE777

Click “Here” Below “Did you doctor share access instructions”

Register yourself and shop for products. Be sure to search for Glutaxym. Use WIRICK10 as a discount code at checkout.


1 Comment

  1. Kathleen Price

    Great information. Thank you.


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